Eflornithine
Definition
Eflornithine: An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
Annotations
DF:DFMO
Other Entries
Difluoromethylornithine
alpha-Difluoromethylornithine
DL-alpha-Difluoromethylornithine
Eflornithine Hydrochloride
Eflornithine Monohydrochloride, Monohydrate
MDL-71,782 A
Ornidyl
RMI 71782
Vaniqa
Women First Brand of Eflornithine Hydrochloride
alpha-Difluoromethyl Ornithine
71782, RMI
DL alpha Difluoromethylornithine
Hydrochloride, Eflornithine
MDL 71,782 A
MDL71,782 A
Monohydrochloride, Monohydrate Eflornithine
Ornithine, alpha-Difluoromethyl
alpha Difluoromethyl Ornithine
alpha Difluoromethylornithine
Previous Index
Ornithine (1966-1974)
Ornithine/analogs & derivatives (1975-1986)
Pharmacy Actions
Antineoplastic Agents
Enzyme Inhibitors
Trypanocidal Agents
Allowable Qualifiers
administration & dosage adverse effects agonists analogs & derivatives analysis antagonists & inhibitors blood cerebrospinal fluid chemical synthesis chemistry classification contraindications diagnostic use economics history immunology isolation & purification metabolism pharmacokinetics pharmacology poisoning radiation effects standards supply & distribution therapeutic use toxicity urine
Categories
Entry Date
06-03-1986
Common Chronic Illnesses
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Diabetes Supplies | Diabetic Groups
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Free Diabetes Supplies
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
